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Article

The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation.

The Journal of biological chemistry - 14 Nov 2008

Fraczek Jerzy, Kim Tae Whan, Xiao Hui, Yao Jianhong, Wen Qian, Li Yali, Casanova Jean-Laurent, Pryjma Juliusz, Li Xiaoxia

Abstract excerpt

Two parallel interleukin-1 (IL-1)-mediated signaling pathways have been uncovered for IL-1R-TLR-mediated NFkappaB activation: TAK1-dependent and MEKK3-dependent pathways, respectively. The TAK1-dependent pathway leads to IKKalpha/beta phosphorylation and IKKbeta activation, resulting in classic NFkappaB activation through IkappaBalpha phosphorylation and degradation. The TAK1-independent MEKK3-dependent pathway...

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Identifiers

PMID: 18794297
DOI: 10.1074/jbc.M804779200
PMCID: PMC2581573

Genes

IRAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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