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Article

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.

Science (New York, N.Y.) - 9 Apr 1999

Delhase M, Hayakawa M, Chen Y, Karin M

Abstract excerpt

IkappaB [inhibitor of nuclear factor kappaB (NF-kappaB)] kinase (IKK) phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses. IKK is composed of three subunits-IKKalpha and IKKbeta, which are highly similar protein kinases, and IKKgamma, a regulatory subunit. In mammalian cells, phosphorylation of two...

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Identifiers

PMID: 10195894
DOI: 10.1126/science.284.5412.309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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