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Article

NF-kappaB RelA phosphorylation regulates RelA acetylation.

Molecular and cellular biology - 1 Sept 2005

Chen Lin-Feng, Williams Samuel A, Mu Yajun, Nakano Hiroyasu, Duerr James M, Buckbinder Leonard, Greene Warner C

Abstract excerpt

The nuclear functions of NF-kappaB p50/RelA heterodimers are regulated in part by posttranslational modifications of its RelA subunit, including phosphorylation and acetylation. Acetylation at lysines 218, 221, and 310 differentially regulates RelA's DNA binding activity, assembly with IkappaBalpha, and transcriptional activity. However, it remains unclear whether the acetylation is regulated or simply due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16135789
DOI: 10.1128/MCB.25.18.7966-7975.2005
PMCID: PMC1234328

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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