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Article

Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner.

The Journal of biological chemistry - 13 Jun 2003

Moran Stewart T, Haider Khaleda, Ow Yongkai, Milton Peter, Chen Luojing, Pillai Shiv

Abstract excerpt

Protein kinase C-associated kinase (PKK, also known as RIP4/DIK) activates NFkappaB when overexpressed in cell lines and is required for keratinocyte differentiation in vivo. However, very little is understood about the factors upstream of PKK or how PKK activates NFkappaB. Here we show that certain catalytically inactive mutants of PKK can activate NFkappaB, although to a lesser degree than wild type PKK. The...

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Identifiers

PMID: 12676934
DOI: 10.1074/jbc.M301575200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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