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Article

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

Molecular and cellular biology - 1 Jul 2000

Bonnet M C, Weil R, Dam E, Hovanessian A G, Meurs E F

Abstract excerpt

The interferon (IFN)-induced double-stranded RNA-activated protein kinase PKR mediates inhibition of protein synthesis through phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) and is also involved in the induction of the IFN gene through the activation of the transcription factor NF-kappaB. NF-kappaB is retained in the cytoplasm through binding to its inhibitor IkappaBalpha. The...

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Identifiers

PMID: 10848580
DOI: 10.1128/MCB.20.13.4532-4542.2000
PMCID: PMC85837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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