Article
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.
Molecular and cellular biology - 1 Jul 2000
Bonnet M C, Weil R, Dam E, Hovanessian A G, Meurs E F
Abstract excerpt
The interferon (IFN)-induced double-stranded RNA-activated protein kinase PKR mediates inhibition of protein synthesis through phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) and is also involved in the induction of the IFN gene through the activation of the transcription factor NF-kappaB. NF-kappaB is retained in the cytoplasm through binding to its inhibitor IkappaBalpha. The...
Topics
- Amino Acid Sequence
- Animals
- Enzyme Activation
- Fibroblasts
- Gene Expression Regulation, Enzymologic
- Glutathione Transferase
- Humans
- I-kappa B Kinase
- Interferons
- Mice
- Mice, Mutant Strains