Identification of a transient excision intermediate at the crossroads between DNA polymerase extension and proofreading pathways.

doi:10.1073/pnas.95.7.3507

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Article

Identification of a transient excision intermediate at the crossroads between DNA polymerase extension and proofreading pathways.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998

Baker R P, Reha-Krantz L J

Abstract excerpt

DNA polymerases achieve accurate DNA replication through a delicate balance between primer elongation and proofreading. While insufficient proofreading results in DNA replication errors, indiscriminate removal of correct along with incorrect nucleotides is wasteful and may prevent completion of D...

Topics

Bacteriophage T4
DNA Mutational Analysis
DNA Replication
DNA, Viral
DNA-Directed DNA Polymerase
Hydrolysis
Mutation

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