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Article

Identification of a transient excision intermediate at the crossroads between DNA polymerase extension and proofreading pathways.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998

Baker R P, Reha-Krantz L J

Abstract excerpt

DNA polymerases achieve accurate DNA replication through a delicate balance between primer elongation and proofreading. While insufficient proofreading results in DNA replication errors, indiscriminate removal of correct along with incorrect nucleotides is wasteful and may prevent completion of DNA synthesis. The transition between polymerization and proofreading modes is proposed to be governed by a kinetic...

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Identifiers

PMID: 9520396
DOI: 10.1073/pnas.95.7.3507
PMCID: PMC19866

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