Article
Multi-stage proofreading in DNA replication.
Quarterly reviews of biophysics - 1 Aug 1993
Beckman R A, Loeb L A
Abstract excerpt
The mechanisms by which DNA polymerases achieve their remarkable fidelity, including base selection and proofreading, are briefly reviewed. Nine proofreading models from the current literature are evaluated in the light of steady-state and transient kinetic studies of E. coli DNA polymerase I, the best-studied DNA polymerase. One model is demonstrated to predict quantitatively the response of DNA polymerase I to...
Topics
- Biophysical Phenomena
- Biophysics
- DNA Polymerase I
- DNA Replication
- Deoxyribonucleotides
- Diphosphates
- Escherichia coli
- Kinetics
- Models, Biological
- Mutation