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Article

Genetic and biochemical studies of bacteriophage T4 DNA polymerase 3'-->5'-exonuclease activity.

The Journal of biological chemistry - 25 Dec 1993

Reha-Krantz L J, Nonay R L

Abstract excerpt

DNA polymerase exonucleolytic proofreading is important in attaining high fidelity DNA replication. One of the most well characterized proofreading activities is the 3'-->5'-exonuclease activity of bacteriophage T4 DNA polymerase. We have used genetic analyses and protein sequence comparisons to Escherichia coli DNA polymerase I to identify amino acids in the N-terminal region of T4 DNA polymerase that are...

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PMID: 8262948

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