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Article

The proofreading pathway of bacteriophage T4 DNA polymerase.

The Journal of biological chemistry - 4 Sept 1998

Reha-Krantz L J, Marquez L A, Elisseeva E, Baker R P, Bloom L B, Dunford H B, Goodman M F

Abstract excerpt

The base analog, 2-aminopurine (2AP), was used as a fluorescent reporter of the biochemical steps in the proofreading pathway catalyzed by bacteriophage T4 DNA polymerase. "Mutator" DNA polymerases that are defective in different steps in the exonucleolytic proofreading pathway were studied so that transient changes in fluorescence intensity could be equated with specific reaction steps. The G255S- and D131N-DNA...

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PMID: 9722519
DOI: 10.1074/jbc.273.36.22969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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