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Article

Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles.

The EMBO journal - 16 Mar 2020

Singh Anupam, Pandey Manjula, Nandakumar Divya, Raney Kevin D, Yin Y Whitney, Patel Smita S

Abstract excerpt

The proofreading exonuclease activity of replicative DNA polymerase excises misincorporated nucleotides during DNA synthesis, but these events are rare. Therefore, we were surprised to find that T7 replisome excised nearly 7% of correctly incorporated nucleotides during leading and lagging strand syntheses. Similar observations with two other DNA polymerases establish its generality. We show that excessive...

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Identifiers

PMID: 32037587
DOI: 10.15252/embj.2019103367
PMCID: PMC7073461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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