Enhancement of the cytotoxicity of mistletoe lectin-1 (ML-1) by high pH or perturbation in Golgi functions.

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Article

Enhancement of the cytotoxicity of mistletoe lectin-1 (ML-1) by high pH or perturbation in Golgi functions.

Die Pharmazie - 1 May 1991

Yoshida T, Zhang M, Chen C, Franz H, Wu H C

Abstract excerpt

We have studied the cytotoxicity of Mistletoe lectin-1 (ML-1), a cytotoxic protein produced by Viscum album, in CHO and V79 cells and in mutant cell lines altered in Golgi functions or in endosomal acidification. In wild-type CHO cells, cytotoxicity of ML-1 was greatly enhanced by ammonium chlori...

Topics

Ammonium Chloride
Animals
Cell Survival
Cricetinae
Cricetulus
Female
Golgi Apparatus
Hydrogen-Ion Concentration
Mutation
Nigericin
Ovary
Plant Preparations
Plant Proteins
Pseudomonas aeruginosa
Ribosome Inactivating Proteins, Type 2
Ricin
Toxins, Biological
Vero Cells

Source

Open in PubMed

Identifiers

PMID: 1910176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1910176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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