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Article

Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection.

Journal of medical virology - 1 Mar 1998

Höhler T, Kruger A, Gerken G, Schneider P M, Meyer zum Büschenfelde K H, Rittner C

Abstract excerpt

Tumor necrosis factor alpha (TNF-alpha) is involved in the pathogenesis of chronic hepatitis C virus infection. The gene for TNF-alpha is encoded in the major histocompatibility locus (MHC). Two polymorphisms at positions -308 and -238 in the TNF-alpha promoter region might influence TNF-alpha ex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9515764
DOI: 10.1002/(sici)1096-9071(199803)54:3<173::aid-jmv5>3.0.co;2-2

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9515764-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection.PMID 9515764Read ↗

Associations of tumour necrosis factor alpha promoter polymorphisms at position -308 and -238 with clinical characteristics of chronic hepatitis C.Semantic proximity Read ↗

A tumor necrosis factor-alpha (TNF-alpha) promoter polymorphism is associated with chronic hepatitis B infection.Semantic proximity Read ↗

The tumour necrosis factor-α-238A allele increases the risk of chronic HBV infection in European populations.Semantic proximity Read ↗

Tumor necrosis factor alpha promoter polymorphisms at position -308 in Taiwanese chronic hepatitis C patients treated with interferon-alpha.Semantic proximity Read ↗

A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China.Semantic proximity Read ↗

Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease.Semantic proximity Read ↗

Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-alpha promoter gene.Semantic proximity Read ↗

Tumor necrosis factor-alpha 308.2 polymorphism is associated with advanced hepatic fibrosis and higher risk for hepatocellular carcinoma.Semantic proximity Read ↗

Tumor necrosis factor-alpha-308A allele may have a protective effect for chronic hepatitis B virus infection in Mongoloid populations.Semantic proximity Read ↗

Tumor necrosis factor-alpha gene promoter polymorphism in Iranian patients with chronic hepatitis B.Semantic proximity Read ↗

TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection.Semantic proximity Read ↗

Tumor necrosis factor-alpha -308G/A polymorphism and risk of hepatocellular carcinoma in hepatitis C virus-infected patients.Semantic proximity Read ↗

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