Article
The tumour necrosis factor-α-238A allele increases the risk of chronic HBV infection in European populations.
Journal of viral hepatitis - 1 Feb 2012
Zheng M-H, Xiao D-D, Lin X-F, Wu S-J, Peng M-M, Yu X-Y, Liu W-Y, Li L-F, Shi K-Q, Fan Y-C, Chen Y-P
Abstract excerpt
Tumour necrosis factor-α (TNF-α) plays a pivotal role in viral clearance and host immune response to hepatitis B virus (HBV) infection, of which the production capacity in individuals is demonstrated to be influenced by a single nucleotide polymorphism within the promoter region of TNF-α genes. However, there have been conflicting results reported in previous studies on TNF-α-238 and TNF-α-863 gene promoter...
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