Article
Tumor necrosis factor-alpha 308.2 polymorphism is associated with advanced hepatic fibrosis and higher risk for hepatocellular carcinoma.
Neoplasia (New York, N.Y.) - 1 Nov 2007
Jeng Jen-Eing, Tsai Jung-Fa, Chuang Lee-Yea, Ho Mei-Shang, Lin Zu-Yau, Hsieh Min-Yuh, Chen Shin-Chern, Chuang Wan-Lung, Wang Liang-Yen, Yu Ming-Lung, Dai Chia-Yen, Chang Jan-Gowth
Abstract excerpt
BACKGROUND/AIMS: Host genetic factor and hepatic fibrosis may predispose to risk for hepatocellular carcinoma (HCC). This study aimed to assess the association between tumor necrosis factor (TNF) alpha polymorphism and hepatic fibrosis, and risk for HCC. METHODS: One hundred eight pairs of gender-matched and age-matched patients with HCC and unrelated healthy controls were genotyped for TNF308.2 and TNF238.2...
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