Article
Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-alpha promoter gene.
Cancer causes & control : CCC - 1 Sept 2004
Ho Sheng-Yow, Wang Ying-Jan, Chen Hen-Li, Chen Chih-Hung, Chang Chih-Jen, Wang Po-Jen, Chen Helen H W, Guo How-Ran
Abstract excerpt
BACKGROUND AND AIMS: Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that may act as an endogenous tumor promoter. A genetic polymorphism of TNF-alpha at position -308 of the promoter region, which includes TNF1 (-308G) and TNF2 (-308A) alleles, has been found to be associated with susceptibility to various types of cancer. We conducted a study to evaluate the association between this polymorphism and...
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