Article
Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population.
Pharmacogenetics - 1 Feb 1998
Griese E U, Zanger U M, Brudermanns U, Gaedigk A, Mikus G, Mörike K, Stüven T, Eichelbaum M
Abstract excerpt
The polymorphic cytochrome P450 CYP2D6 catalyses the biotransformation of at least 40 drugs. The CYP2D6 genetic polymorphism is responsible for pronounced interindividual differences in plasma concentrations and, hence, in drug action and side-effects after administration of the same dose. Provided there is a close relationship between CYP2D6 genotypes and catalytic function, genotyping could be used in the...
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