Article
CYP2D6 genotype determination in the Danish population.
European journal of clinical pharmacology - 1 Jan 1994
Brøsen K, Nielsen P N, Brusgaard K, Gram L F, Skjødt K
Abstract excerpt
CYP2D6 genotyping was carried out by XbaI restriction fragment length polymorphism analysis and polymerase chain reaction in 168 healthy Danish volunteers, 77 extensive metabolizers (EM) and 91 poor metabolizers (PM) of sparteine. All EM were genotyped correctly as heterozygous or homozygous for the functional (wild type) gene, D6-wt. However, the D6-wt gene was apparently also present in 11 (12%) of the PM who...
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