Article
Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency.
Clinical chemistry - 1 Feb 1997
Linder M W, Prough R A, Valdes R
Abstract excerpt
Pharmacogenetics is the study of the linkage between an individual's genotype and that individual's ability to metabolize a foreign compound. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration...
Topics
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Genotype
- Humans
- Isoenzymes
- Mutation
- Pharmaceutical Preparations
- Pharmacogenetics
- Phenotype