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Article

Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency.

Clinical chemistry - 1 Feb 1997

Linder M W, Prough R A, Valdes R

Abstract excerpt

Pharmacogenetics is the study of the linkage between an individual's genotype and that individual's ability to metabolize a foreign compound. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Phenotypes exhibiting poor and ultraextensive metabolism result from genetic...

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PMID: 9023127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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