Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency

Abstract excerpt

Abstract Pharmacogenetics is the study of the linkage between an individual’s genotype and that individual’s ability to metabolize a foreign compound. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Phenotypes exhibiting poor and ultraextensive metabolism result from gene...

Topics

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• Drug Transport and Resistance Mechanisms
• Pharmacogenetics and Drug Metabolism
• Pharmacological Effects and Toxicity Studies

Identifiers and source

Literature Corpus work

6a5365b9-b2da-5c9c-ad2f-6a073c0668f2

DOI

10.1093/clinchem/43.2.254