Article
Nucleotide variations in intron 1 of the renin gene of the spontaneously hypertensive rat.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 1998
Di Nicolantonio R, Lan L, Wilks A
Abstract excerpt
The renin gene is known to be overexpressed in the spontaneously hypertensive rat (SHR) of the Okamoto strain. As the first intron of many genes controls transcription rate, we examined whether the first 1,100 base pairs of the SHR first intron possessed mutations in putative transcriptional factor binding sites. Such mutations might then form the basis for overexpression of the renin gene in the SHR. A BglII...
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