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Article

Existence of a mutation of angiotensin AT1 receptor gene promoter region involved in inhibition of AT1 receptor gene transcription in spontaneously hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 2003

Kambe Toshie, Hiruki Hitoshi, Kubo Takao

Abstract excerpt

The angiotensin type 1a (AT1a) receptor gene is overexpressed in the brain and peripheral tissues of spontaneously hypertensive rats (SHR). We examined whether there are mutations responsible for overexpression of the AT1a receptor gene in the SHR AT1a receptor promoter region. Genomic DNA was extracted from the livers of SHR and Wistar Kyoto rats (WKY) of Izumo strain (SHR/Izm and WKY/Izm, respectively)....

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PMID: 12675280
DOI: 10.1291/hypres.26.245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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