Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations.

doi:10.1097/00004872-199008000-00011

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Article

Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations.

Journal of hypertension - 1 Aug 1990

Lindpaintner K, Takahashi S, Ganten D

Abstract excerpt

Primary hypertension is considered a polygenic, inherited disorder; to date, the nature of the genes involved remains unknown. In this study we present evidence for a structural difference in the gene coding for renin between the stroke-prone, spontaneously hypertensive rat (SHRSP) and its normot...

Topics

Animals
Blotting, Southern
Cerebrovascular Disorders
Female
Genotype
Hypertension
Introns
Male
Phenotype
Polymorphism, Restriction Fragment Length
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Renin

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