Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospholipase C-delta gene of the spontaneously hypertensive rat harbors point mutations causing amino acid substitutions in a catalytic domain.

Journal of hypertension - 1 Nov 1991

Yagisawa H, Tanase H, Nojima H

Abstract excerpt

This study was undertaken in order to investigate the newly discovered spontaneously hypertensive rat (SHR)-specific restriction fragment length polymorphism (RFLP) at the genomic locus of (poly)phosphoinositide-specific phospholipase C (PLC)-delta at a DNA sequence level. Our aim was to clone the PLC-delta complimentary DNA (cDNA) from SHR and analyse the genomic DNA obtained from two hypertensive rat strains...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
DNA
Hypertension
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred SHR

Rats, Inbred Strains

Rats, Inbred WKY

Type C Phospholipases

Source

Identifiers

PMID: 1684614
DOI: 10.1097/00004872-199111000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1684614-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospholipase C-delta gene of the spontaneously hypertensive rat harbors point mutations causing amino acid substitutions in a catalytic domain.PMID 1684614Read ↗

Altered structure, regulation, and function of the gene encoding the atrial natriuretic peptide in the stroke-prone spontaneously hypertensive rat.Semantic proximity Read ↗

Genotypes of sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase II gene in substrains of spontaneously hypertensive rats.Semantic proximity Read ↗

Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat.Semantic proximity Read ↗

Nucleotide variations in intron 1 of the renin gene of the spontaneously hypertensive rat.Semantic proximity Read ↗

Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations.Semantic proximity Read ↗

Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats. A study on cause and effect.Semantic proximity Read ↗

Novel mutation in the first intron of the spontaneously hypertensive rat renin gene upstream of the tandem repeat element.Semantic proximity Read ↗

Dde I restriction fragment length polymorphism of the alpha 2-adrenoceptor gene does not correlate with blood pressure in the F2 generation obtained from crossing stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.Semantic proximity Read ↗

Prague hereditary hypercholesterolemic (PHHC) rat - a model of polygenic hypercholesterolemia.Semantic proximity Read ↗

Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm.Semantic proximity Read ↗

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats.Semantic proximity Read ↗

Genetic divergence between the Wistar-Kyoto rat and the spontaneously hypertensive rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.