Altered nuclear protein binding to the first intron of the renin gene of the spontaneously hypertensive rat.

doi:10.3109/10641969809053249

Back to search

Article

Altered nuclear protein binding to the first intron of the renin gene of the spontaneously hypertensive rat.

Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Nov 1998

Yu H, Di Nicolantonio R

Abstract excerpt

We and others have reported elevated levels of renin mRNA in extrarenal tissues of the spontaneously hypertensive rat (SHR) of the Okamoto strain. We hypothesise that this is due to mutations we have found in putative, cis-regulatory regions in the first intron of its renin gene. Here we report t...

Topics

Animals
DNA-Binding Proteins
Hypertension
Introns
Mutation
Nuclear Proteins
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Renin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.