Article
Altered nuclear protein binding to the first intron of the renin gene of the spontaneously hypertensive rat.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Nov 1998
Yu H, Di Nicolantonio R
Abstract excerpt
We and others have reported elevated levels of renin mRNA in extrarenal tissues of the spontaneously hypertensive rat (SHR) of the Okamoto strain. We hypothesise that this is due to mutations we have found in putative, cis-regulatory regions in the first intron of its renin gene. Here we report two G-A mutations at position +502 and +934 of the first intron of the SHR renin gene, when compared to normotensive...
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