Article
Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats. A study on cause and effect.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 1995
Hübner N, Kreutz R, Takahashi S, Ganten D, Lindpaintner K
Abstract excerpt
The components of the renin-angiotensin system have been implicated in the development of primary hypertension in humans and genetically hypertensive rats. In humans a mutation in the angiotensinogen gene and elevated plasma angiotensinogen levels have been linked to primary hypertension. Althoug...
Topics
- Alleles
- Amino Acid Sequence
- Angiotensin II
- Angiotensinogen
- Animals
- Base Sequence
- Female
- Genetic Linkage
- Hypertension
- Male
- Molecular Sequence Data
- Point Mutation
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Sodium, Dietary