Article
Role of the Xist gene in X chromosome choosing.
Cell - 6 Mar 1998
Marahrens Y, Loring J, Jaenisch R
Abstract excerpt
In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion...
Topics
- Animals
- Animals, Newborn
- Body Weight
- Dosage Compensation, Genetic
- Exons
- Female
- Fetus
- Gene Expression Regulation, Developmental
- Heterozygote
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Mutant Strains
- Models, Genetic
- Phenotype
- RNA, Long Noncoding
- RNA, Messenger
- RNA, Untranslated