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Article

Role of the Xist gene in X chromosome choosing.

Cell - 6 Mar 1998

Marahrens Y, Loring J, Jaenisch R

Abstract excerpt

In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, which includes part of exon 1 and extends to exon 5, undergo primary nonrandom inactivation of the...

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Identifiers

PMID: 9506520
DOI: 10.1016/s0092-8674(00)81133-2

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The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.Semantic proximity Read ↗

X-chromosome inactivation and human genetic disease.Semantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

A long noncoding RNA influences the choice of the X chromosome to be inactivated.Semantic proximity Read ↗

Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse.Semantic proximity Read ↗

Embryonic loss of human females with partial trisomy 19 identifies region critical for the single active XSemantic proximity Read ↗

Autosomal dominant mutations affecting X inactivation choice in the mouse.Semantic proximity Read ↗

Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line.Semantic proximity Read ↗

Unleashing XIST from X-chromosome inactivationSemantic proximity Read ↗

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