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Article

Autosomal dominant mutations affecting X inactivation choice in the mouse.

Science (New York, N.Y.) - 10 May 2002

Percec Ivona, Plenge Robert M, Nadeau Joseph H, Bartolomei Marisa S, Willard Huntington F

Abstract excerpt

X chromosome inactivation is the silencing mechanism eutherian mammals use to equalize the expression of X-linked genes between males and females early in embryonic development. In the mouse, genetic control of inactivation requires elements within the X inactivation center (Xic) on the X chromosome that influence the choice of which X chromosome is to be inactivated in individual cells. It has long been posited...

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Identifiers

PMID: 12004136
DOI: 10.1126/science.1070087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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