Article
Requirement for Xist in X chromosome inactivation.
Nature - 11 Jan 1996
Penny G D, Kay G F, Sheardown S A, Rastan S, Brockdorff N
Abstract excerpt
The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its ab...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Chimera
- Clone Cells
- DNA Primers
- Dosage Compensation, Genetic
- Embryo, Mammalian
- Female
- Gene Targeting
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutagenesis
- RNA, Long Noncoding