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Article

Requirement for Xist in X chromosome inactivation.

Nature - 11 Jan 1996

Penny G D, Kay G F, Sheardown S A, Rastan S, Brockdorff N

Abstract excerpt

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

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PMID: 8538762
DOI: 10.1038/379131a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for Xist in X chromosome inactivation.PMID 8538762Read ↗

Advances in understanding chromosome silencing by the long non-coding RNA Xist.Semantic proximity Read ↗

Unleashing XIST from X-chromosome inactivationSemantic proximity Read ↗

A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene TsxSemantic proximity Read ↗

Role of the Xist gene in X chromosome choosing.Semantic proximity Read ↗

Chromosomal silencing and localization are mediated by different domains of Xist RNA.Semantic proximity Read ↗

De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation.Semantic proximity Read ↗

Evolutionary conservation of possible functional domains of the human and murine XIST genes.Semantic proximity Read ↗

Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expressionSemantic proximity Read ↗

Ongoing Hurdles in Harnessing Xist to Treat Human Disease: Review ArticleSemantic proximity Read ↗

X-chromosome inactivation: the molecular basis of silencing.Semantic proximity Read ↗

Independent recruitment of PRC1 and PRC2 by human XISTSemantic proximity Read ↗

Chromatin structure analysis of the mouse Xist locus.Semantic proximity Read ↗

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