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Article

X-chromosome inactivation and human genetic disease.

Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Jan 2002

Lyon M F

Abstract excerpt

UNLABELLED: The inactivation of one X-chromosome in females in early development is the process by which the effective dosage of X-linked genes is equalized between XX females and XY males. The mechanism that brings this about is the subject of intense research. The X-linked gene Xist is a key player, which is necessary but not sufficient for the initiation of X-inactivation. It codes for an untranslated RNA that...

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Share to Chromosomes, Human, X
Share to Gene Expression Regulation
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Hypothalamic control of reproductive hormones

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Source

Identifiers

PMID: 12572852
DOI: 10.1111/j.1651-2227.2002.tb03120.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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