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Article

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 1998

Claycomb W C, Lanson N A, Stallworth B S, Egeland D B, Delcarpio J B, Bahinski A, Izzo N J

Abstract excerpt

We have derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial cardiomyocyte tumor lineage. HL-1 cells can be serially passaged, yet they maintain the ability to contract and retain differentiated cardiac morphological, biochemical, and electrophysiological properties. Ultrastructural characteristics typical of embryonic atrial cardiac muscle cells were found consistently in the cultured...

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Identifiers

PMID: 9501201
DOI: 10.1073/pnas.95.6.2979
PMCID: PMC19680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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