Article
Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice.
The American journal of physiology - 1 Dec 1990
Steinhelper M E, Lanson N A, Dresdner K P, Delcarpio J B, Wit A L, Claycomb W C, Field L J
Abstract excerpt
Transgenic mice expressing atrial natriuretic factor-SV40 T-antigen fusion genes (ANF-TAG) developed unilateral right atrial tumors composed of differentiated dividing cardiomyocytes. The atrial tumors could be propagated as transplantable tumor lineages in syngeneic animals. Cardiomyocytes derived from ANF-TAG atrial tumors did not proliferate in tissue culture. However, cardiomyocytes derived from the...
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