Article
Proliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice.
The American journal of physiology - 1 Dec 1990
Steinhelper M E, Lanson N A, Dresdner K P, Delcarpio J B, Wit A L, Claycomb W C, Field L J
Abstract excerpt
Transgenic mice expressing atrial natriuretic factor-SV40 T-antigen fusion genes (ANF-TAG) developed unilateral right atrial tumors composed of differentiated dividing cardiomyocytes. The atrial tumors could be propagated as transplantable tumor lineages in syngeneic animals. Cardiomyocytes deriv...
Topics
- Animals
- Antigens, Viral, Tumor
- Atrial Natriuretic Factor
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Cloning, Molecular
- Culture Techniques
- Heart Atria
- Heart Transplantation
- Mice
- Mice, Transgenic
- Myocardium
- Neoplasm Transplantation
- Phenotype
- Simian virus 40
- Tumor Cells, Cultured