Article
Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair.
Cardiovascular research - 1 Dec 2007
Martínez-Mármol Ramón, David Miren, Sanches Rosario, Roura-Ferrer Meritxell, Villalonga Núria, Sorianello Eleonora, Webb Susan M, Zorzano Antonio, Gumà Anna, Valenzuela Carmen, Felipe Antonio
Abstract excerpt
OBJECTIVE: Cellular cardiomyoplasty using skeletal myoblasts is a promising therapy for myocardial infarct repair. Once transplanted, myoblasts grow, differentiate and adapt their electrophysiological properties towards more cardiac-like phenotypes. Voltage-dependent Na(+) channels (Na(v)) are the main proteins involved in the propagation of the cardiac action potential, and their phenotype affects cardiac...
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