Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells.

doi:10.1371/journal.pone.0052032

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Article

Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells.

PloS one - 1 Jan 2012

Dawson Kristin, Wu Chia-Tung, Qi Xiao Yan, Nattel Stanley

Abstract excerpt

INTRODUCTION: Fibroblasts are important in the atrial fibrillation (AF) substrate resulting from congestive heart failure (CHF). We previously noted changes in in vivo indices of fibroblast function in a CHF dog model, but could not detect changes in isolated cells. This study assessed CHF-induced changes in the phenotype of fibroblasts freshly isolated from control versus CHF dogs, and examined effects of cell...

Topics

Animals
Cells, Cultured
Collagen
Disease Models, Animal
Dogs
Down-Regulation
Extracellular Matrix
Fibroblasts
Fibronectins
Gene Expression
Heart Atria
Heart Failure
Male
Myocardium
Phenotype
Potassium

Source

Open in PubMed Open full text

Identifiers

PMID: 23251678
DOI: 10.1371/journal.pone.0052032
PMCID: PMC3522639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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