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Article

Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells.

PloS one - 1 Jan 2012

Dawson Kristin, Wu Chia-Tung, Qi Xiao Yan, Nattel Stanley

Abstract excerpt

INTRODUCTION: Fibroblasts are important in the atrial fibrillation (AF) substrate resulting from congestive heart failure (CHF). We previously noted changes in in vivo indices of fibroblast function in a CHF dog model, but could not detect changes in isolated cells. This study assessed CHF-induced changes in the phenotype of fibroblasts freshly isolated from control versus CHF dogs, and examined effects of cell...

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Identifiers

PMID: 23251678
DOI: 10.1371/journal.pone.0052032
PMCID: PMC3522639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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