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Article

ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes

26 Jun 2018

Abstract excerpt

Rapid impulse propagation is a defining attribute of the pectinated atrial myocardium and His-Purkinje system (HPS) that safeguards against atrial and ventricular arrhythmias, conduction block, and myocardial dyssynchrony. The complex transcriptional circuitry that dictates rapid conduction remains incompletely understood. Here, we demonstrate that ETV1 (ER81)-dependent gene networks dictate the unique...

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PMID: 29967479
DOI: 10.1038/s41598-018-28239-7

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