Article
Use of first nucleotide change technology to determine the frequency of factor V Leiden in a population of Australian blood donors.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Nov 1997
Pecheniuk N M, Marsh N A, Walsh T P, Dale J L
Abstract excerpt
Activated protein C resistance (APCR), the most common risk factor for venous thrombosis, is the result of a G to A base substitution at nucleotide 1691 (R506Q) in the factor V gene. Current techniques to detect the factor V Leiden mutation, such as determination of restriction length polymorphisms, do not have the capacity to screen large numbers of samples in a rapid, cost-effective test. The aim of this study...
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