Diagnosis strategies in activated protein C resistance: is genotyping still necessary?

doi:10.1046/j.1365-2257.1997.00209.x

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Article

Diagnosis strategies in activated protein C resistance: is genotyping still necessary?

Clinical and laboratory haematology - 1 Mar 1997

Biron C, Lamarti H, Schved J F, Jeanjean P, Masmejean C, Claustres M, Aguilar-Martinez P

Abstract excerpt

Resistance to activated protein C (APC) is due, in most cases, to a G to A mutation at nucleotide 1691 of factor V (FV) gene (the Leiden mutation). This inherited abnormality is now considered to be the major hereditary cause associated with an elevated risk of thrombosis. For this reason, labora...

Topics

Blood Coagulation Disorders
Blood Coagulation Tests
Electrophoresis, Polyacrylamide Gel
Factor V
Genotype
Heterozygote
Homozygote
Humans
Mutation
Pedigree
Protein C
Risk Factors

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