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Article

Diagnosis strategies in activated protein C resistance: is genotyping still necessary?

Clinical and laboratory haematology - 1 Mar 1997

Biron C, Lamarti H, Schved J F, Jeanjean P, Masmejean C, Claustres M, Aguilar-Martinez P

Abstract excerpt

Resistance to activated protein C (APC) is due, in most cases, to a G to A mutation at nucleotide 1691 of factor V (FV) gene (the Leiden mutation). This inherited abnormality is now considered to be the major hereditary cause associated with an elevated risk of thrombosis. For this reason, laboratories are faced with an increasing number of samples referred for APC resistance diagnosis. This could have serious...

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Source

Identifiers

PMID: 9146951
DOI: 10.1046/j.1365-2257.1997.00209.x

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Diagnosis strategies in activated protein C resistance: is genotyping still necessary?PMID 9146951Read ↗

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Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden.Semantic proximity Read ↗

An alternative method for identifying the factor V gene Leiden mutation.Semantic proximity Read ↗

Use of modified functional assays for activated protein C resistance in patients with basally prolonged aPTT.Semantic proximity Read ↗

Clinical evaluation of a new functional test for detection of activated protein C resistance (Pefakit APC-R Factor V Leiden) at two centers in Europe and the USA.Semantic proximity Read ↗

A modification of the APC resistance test and its application to the study of patients on coumarin therapy.Semantic proximity Read ↗

High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis.Semantic proximity Read ↗

The 1691 G-->A mutation in the factor V gene: relationship to activated protein C (APC) resistance and thrombosis in 65 patients.Semantic proximity Read ↗

Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.Semantic proximity Read ↗

Evaluation of original and modified APC-resistance tests in unselected outpatients with clinically suspected thrombosis and in healthy controls.Semantic proximity Read ↗

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