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Article

An alternative method for identifying the factor V gene Leiden mutation.

Thrombosis research - 15 Jan 1997

Lewandowski K, Rozek M, Zawilska K, Markiewicz W T

Abstract excerpt

The recently described point mutation of nucleotide 1691 of the factor V gene is responsible for the factor V resistance to a cleavage with an activated protein C (APC-resistance). Despite the high sensitivity and specificity of the APC-resistance test as a screening method for the detection of the factor V APC-resistance, there is still a necessity to develop a simple, cheap and accurate DNA-based assay. Herein,...

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Source

Identifiers

PMID: 9058484
DOI: 10.1016/s0049-3848(96)00227-7

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An alternative method for identifying the factor V gene Leiden mutation.PMID 9058484Read ↗

The 1691 G-->A mutation in the factor V gene: relationship to activated protein C (APC) resistance and thrombosis in 65 patients.Semantic proximity Read ↗

A matrix-assisted laser desorption/ionization time-of-flight based method for screening the 1691G --> A mutation in the factor V gene.Semantic proximity Read ↗

Venous thrombosis: factor V G1691A genotyping related to APC resistance as measured by 2 methods.Semantic proximity Read ↗

Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.Semantic proximity Read ↗

Two novel factor V null mutations associated with activated protein C resistance phenotype/genotype discrepancy.Semantic proximity Read ↗

Diagnosis strategies in activated protein C resistance: is genotyping still necessary?Semantic proximity Read ↗

A modification of the APC resistance test and its application to the study of patients on coumarin therapy.Semantic proximity Read ↗

Use of the direct RNA amplification technique NASBA to detect factor V Leiden, a point mutation associated with APC resistance.Semantic proximity Read ↗

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Discrimination between normal wildtype and carriers of coagulation factor V Leiden mutation by the activated protein C resistance test in the presence of factor V deficient plasma.Semantic proximity Read ↗

Rapid genotyping of factor V Leiden mutation using single-tube bidirectional allele-specific amplification and automated ultrathin-layer agarose gel electrophoresis.Semantic proximity Read ↗

High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis.Semantic proximity Read ↗

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