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Article

Phenotyping and genotyping of coagulation factor V Leiden.

Thrombosis and haemostasis - 1 Feb 1996

Engel H, Zwang L, van Vliet H H, Michiels J J, Stibbe J, Lindemans J

Abstract excerpt

The currently used activated Protein C resistance test demonstrated to be of limited diagnostic value for the detection of the mutant Factor V Leiden. Moreover, this assay is not useful for patients under anticoagulant therapy. A modification of the APC resistance test, applying Factor V deficient plasma is described which demonstrates a specificity and sensitivity of 1.0. The superiority of the modified APC...

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Source

Identifiers

PMID: 8815574

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotyping and genotyping of coagulation factor V Leiden.PMID 8815574Read ↗

Diagnosis strategies in activated protein C resistance: is genotyping still necessary?Semantic proximity Read ↗

Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.Semantic proximity Read ↗

Discrimination between normal wildtype and carriers of coagulation factor V Leiden mutation by the activated protein C resistance test in the presence of factor V deficient plasma.Semantic proximity Read ↗

High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis.Semantic proximity Read ↗

Venous thrombosis: factor V G1691A genotyping related to APC resistance as measured by 2 methods.Semantic proximity Read ↗

The 1691 G-->A mutation in the factor V gene: relationship to activated protein C (APC) resistance and thrombosis in 65 patients.Semantic proximity Read ↗

Sensitivity and specificity of the APC resistance assay in detection of individuals with factor V Leiden.Semantic proximity Read ↗

An alternative method for identifying the factor V gene Leiden mutation.Semantic proximity Read ↗

Clinical evaluation of a new functional test for detection of activated protein C resistance (Pefakit APC-R Factor V Leiden) at two centers in Europe and the USA.Semantic proximity Read ↗

Phenotypic homozygous activated protein C resistance associated with compound heterozygosity for Arg506Gln (factor V Leiden) and His1299Arg substitutions in factor V.Semantic proximity Read ↗

A modification of the APC resistance test and its application to the study of patients on coumarin therapy.Semantic proximity Read ↗

ARMS test for diagnosis of factor V Leiden mutation and allele frequencies in France.Semantic proximity Read ↗

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