Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.

doi:10.1002/(sici)1098-2825(1997)11:6<328::aid-jcla3>3.0.co;2-1

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Article

Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.

Journal of clinical laboratory analysis - 1 Jan 1997

Ferreira-Gonzalez A, Fisher L M, Lehman C M, Langley M H, Lofland D H, Xia Q, Nguyen N X, Modesto D, Willoughby J B, Wilkinson D S, Garrett C T

Abstract excerpt

Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measur...

Topics

Black People
DNA
DNA Mutational Analysis
Drug Resistance
Factor V
Gene Frequency
Heterozygote
Homozygote
Humans
Mutation
Partial Thromboplastin Time

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Protein C

Sensitivity and Specificity

Thrombosis

White People

Black or African American

Source

Open in PubMed Open full text

Identifiers

PMID: 9406051
DOI: 10.1002/(sici)1098-2825(1997)11:6<328::aid-jcla3>3.0.co;2-1
PMCID: PMC6760686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9406051-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.PMID 9406051Read ↗

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