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Article

Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.

Journal of clinical laboratory analysis - 1 Jan 1997

Ferreira-Gonzalez A, Fisher L M, Lehman C M, Langley M H, Lofland D H, Xia Q, Nguyen N X, Modesto D, Willoughby J B, Wilkinson D S, Garrett C T

Abstract excerpt

Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured a prevalence of 3.3% in healthy Caucasians and 1.25% in healthy African-Americans. In addition, we evaluated a total...

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Identifiers

PMID: 9406051
DOI: 10.1002/(sici)1098-2825(1997)11:6<328::aid-jcla3>3.0.co;2-1
PMCID: PMC6760686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detection of a common mutation in factor V gene responsible for resistance to activate protein C causing predisposition to thrombosis.PMID 9406051Read ↗

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The 1691 G-->A mutation in the factor V gene: relationship to activated protein C (APC) resistance and thrombosis in 65 patients.Semantic proximity Read ↗

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Clinical evaluation of a new functional test for detection of activated protein C resistance (Pefakit APC-R Factor V Leiden) at two centers in Europe and the USA.Semantic proximity Read ↗

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