Article
Use of the direct RNA amplification technique NASBA to detect factor V Leiden, a point mutation associated with APC resistance.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 1996
Reitsma P H, van der Velden P A, Vogels E, van Strijp D, Tacken N, Adriaansen H, van Gemen B
Abstract excerpt
APC resistance is a common and strong hereditary risk factor for venous thrombosis. This plasma abnormality appears to be almost always caused by the same defect in the coagulation factor V gene (a G --> A transition at nucleotide 1691 leading to replacement of 506 Arg by Gln; factor V Leiden). Therefore, it is possible to consider a simple and specific genetic test as an alternative to a plasma APC resistance...
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