Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin D1 Amplification and p16(MTS1/CDK4I) Deletion Correlate With Poor Prognosis in Head and Neck Tumors

1 Mar 2002

Abstract excerpt

OBJECTIVES/HYPOTHESIS: Cyclin D1, a cell cycle regulator localized to chromosome 11q13, is amplified in several human tumors including head and neck squamous cell carcinoma (HNSCC). Amplification and/or overexpression of cyclin D1 have been correlated to a poor prognosis. Deletion of the p16 gene, localized to 9p21, has also been observed in a significant proportion of HNSCC. The p16 gene regulates cyclin D1-CDK4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Research and Disease Studies
Share to Cancer-related Molecular Pathways
Share to Head and Neck Cancer Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12148857
DOI: 10.1097/00005537-200203000-00013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin D1 Amplification and p16(MTS1/CDK4I) Deletion Correlate With Poor Prognosis in Head and Neck TumorsPMID 12148857Read ↗

Chromosome 11q13 Amplification in Head and Neck Squamous Cell Carcinoma: Association With Poor PrognosisSemantic proximity Read ↗

Chromosome 11Q13 Amplification in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression.Semantic proximity Read ↗

Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV.Semantic proximity Read ↗

Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal CarcinomaSemantic proximity Read ↗

Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications.Semantic proximity Read ↗

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.Semantic proximity Read ↗

An update on the implications of cyclin D1 in oral carcinogenesisSemantic proximity Read ↗

Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.Semantic proximity Read ↗

Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity.Semantic proximity Read ↗

Fine-Mapping Loss of Gene Architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP Genes in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Clinical correlates of promoter hypermethylation of four target genes in head and neck cancer: a cooperative group correlative study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.