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Article

Immune evasion in HPV − head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss

5 May 2021

Abstract excerpt

Significance We report somatic copy-number alterations (SCNAs) that contribute to an immune microenvironment switch during human papillomavirus-negative head and neck cancer (HNSC) development. Specific and nonspecific SCNA levels were examined in a large prospective oral precancer (188 patients) cohort, 2 HNSC (343, 196 patients) cohorts, and 32 cell lines. Chromosome 9p21.3 loss in precursor lesions, the...

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PMID: 33952700
DOI: 10.1073/pnas.2022655118

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