Article
Independent versus coupled inactivation in sodium channels. Role of the domain 2 S4 segment.
The Journal of general physiology - 1 Mar 1998
Mitrovic N, George A L, Horn R
Abstract excerpt
The voltage sensor of the sodium channel is mainly comprised of four positively charged S4 segments. Depolarization causes an outward movement of S4 segments, and this movement is coupled with opening of the channel. A mutation that substitutes a cysteine for the outermost arginine in the S4 segm...
Topics
- Amino Acid Substitution
- Arginine
- Cysteine
- Electric Stimulation
- Electrophysiology
- In Vitro Techniques
- Ion Channel Gating
- Kinetics
- Mutagenesis, Site-Directed
- Mutation
- Patch-Clamp Techniques
- Sodium Channels