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Article

Independent versus coupled inactivation in sodium channels. Role of the domain 2 S4 segment.

The Journal of general physiology - 1 Mar 1998

Mitrovic N, George A L, Horn R

Abstract excerpt

The voltage sensor of the sodium channel is mainly comprised of four positively charged S4 segments. Depolarization causes an outward movement of S4 segments, and this movement is coupled with opening of the channel. A mutation that substitutes a cysteine for the outermost arginine in the S4 segment of the second domain (D2:R1C) results in a channel with biophysical properties similar to those of wild-type...

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Identifiers

PMID: 9482711
DOI: 10.1085/jgp.111.3.451
PMCID: PMC2217117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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