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Article

Different pathways for activation and deactivation in CaV1.2: a minimal gating model.

The Journal of general physiology - 1 Sept 2009

Beyl Stanislav, Kügler Philipp, Kudrnac Michaela, Hohaus Annette, Hering Steffen, Timin Eugen

Abstract excerpt

Point mutations in pore-lining S6 segments of CaV1.2 shift the voltage dependence of activation into the hyperpolarizing direction and significantly decelerate current activation and deactivation. Here, we analyze theses changes in channel gating in terms of a circular four-state model accounting...

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Identifiers

PMID: 19687230
DOI: 10.1085/jgp.200910272
PMCID: PMC2737230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19687230-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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