Over-expression of the yeast BFR2 gene partially suppresses the growth defects induced by Brefeldin A and by four ER-to-Golgi mutations.

doi:10.1007/s002940050304

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Article

Over-expression of the yeast BFR2 gene partially suppresses the growth defects induced by Brefeldin A and by four ER-to-Golgi mutations.

Current genetics - 1 Jan 1998

Chabane S, Gachet E, Képès F

Abstract excerpt

The fungal metabolite Brefeldin A (BFA) disrupts the Golgi apparatus and its incoming protein flux. We developed a genetic approach to identify yeast proteins involved in the protein transport step that BFA blocks. The BFR2 gene (YDR299W) was thus isolated as a high-copy suppressor of the growth...

Topics

Antifungal Agents
Brefeldin A
Cyclopentanes
Endoplasmic Reticulum
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Suppressor
Golgi Apparatus
Mutation
Nystatin
Organelles
Receptors, Fibroblast Growth Factor
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 9472076
DOI: 10.1007/s002940050304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9472076-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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