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Article

Effects of brefeldin A on the three-dimensional structure of the Golgi apparatus in a sensitive strain of Saccharomyces cerevisiae.

The Anatomical record - 1 Jan 1995

Rambourg A, Clermont Y, Jackson C L, Képès F

Abstract excerpt

BACKGROUND: Brefeldin A (BFA), when added to the medium of cultured mammalian cells, induces a reversible block of secretion and disrupts the Golgi apparatus whereas Golgi enzyme markers appear to redistribute into the endoplasmic reticulum (ER). It has been shown in addition that in mammalian cells, BFA would prevent the assembly of coatomer proteins (COP) onto membranes by inhibiting the GTP-dependent...

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Identifiers

PMID: 7879913
DOI: 10.1002/ar.1092410102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effects of brefeldin A on the three-dimensional structure of the Golgi apparatus in a sensitive strain of Saccharomyces cerevisiae.PMID 7879913Read ↗

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.Semantic proximity Read ↗

BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.Semantic proximity Read ↗

Over-expression of the yeast BFR2 gene partially suppresses the growth defects induced by Brefeldin A and by four ER-to-Golgi mutations.Semantic proximity Read ↗

ARF is required for maintenance of yeast Golgi and endosome structure and function.Semantic proximity Read ↗

Sec7p directs the transitions required for yeast Golgi biogenesis.Semantic proximity Read ↗

DS28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses key phenotypic changes associated with brefeldin A treatment.Semantic proximity Read ↗

Modifications of the Golgi apparatus in Saccharomyces cerevisiae lacking microtubules.Semantic proximity Read ↗

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.Semantic proximity Read ↗

Brefeldin A sensitivity and resistance in Schizosaccharomyces pombe. Isolation of multiple genes conferring resistance.Semantic proximity Read ↗

CopA:GFP localizes to putative Golgi equivalents in Aspergillus nidulans.Semantic proximity Read ↗

Modulation of the Golgi apparatus in Saccharomyces cerevisiae sec7 mutants as seen by three-dimensional electron microscopy.Semantic proximity Read ↗

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