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Article

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.

The Journal of biological chemistry - 15 Feb 1993

Vogel J P, Lee J N, Kirsch D R, Rose M D, Sztul E S

Abstract excerpt

Brefeldin A (BFA) blocks secretion in mammalian cells and causes the redistribution of Golgi resident membrane proteins to the endoplasmic reticulum (Klausner, R. D., Donaldson, J. G., and Lippincott-Schwartz, J. (1992) J. Cell Biol. 116, 1071-1080). The target(s) of BFA and its mechanism of action remain unknown. The yeast Saccharomyces cerevisiae represents an ideal organism in which to identify the BFA...

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PMID: 8428980

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Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae.PMID 8428980Read ↗

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Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.Semantic proximity Read ↗

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Effects of brefeldin A on the three-dimensional structure of the Golgi apparatus in a sensitive strain of Saccharomyces cerevisiae.Semantic proximity Read ↗

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A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast.Semantic proximity Read ↗

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.Semantic proximity Read ↗

Specific sterols required for the internalization step of endocytosis in yeast.Semantic proximity Read ↗

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Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors.Semantic proximity Read ↗

A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae.Semantic proximity Read ↗

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