Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.

doi:10.1002/j.1460-2075.1993.tb05727.x

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Article

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.

The EMBO journal - 1 Mar 1993

Graham T R, Scott P A, Emr S D

Abstract excerpt

We have found that brefeldin A (BFA) inhibited the growth of an ise1 mutant of Saccharomyces cerevisiae. Genetic complementation and mapping studies demonstrated that ise1 was allelic to erg6, a gene required for the biosynthesis of the principal membrane sterol of yeast, ergosterol. Treatment of ise1 cells with BFA resulted in an immediate block in protein transport through the secretory pathway. Vacuolar...

Topics

Biological Transport
Brefeldin A
Carboxypeptidases
Cathepsin A
Cyclopentanes
Endoplasmic Reticulum
Fungal Proteins
Genes, Fungal
Genetic Complementation Test
Mating Factor
Mutation
Mycotoxins
Peptides
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 8458343
DOI: 10.1002/j.1460-2075.1993.tb05727.x
PMCID: PMC413285

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