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Article

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.

The EMBO journal - 1 Mar 1993

Graham T R, Scott P A, Emr S D

Abstract excerpt

We have found that brefeldin A (BFA) inhibited the growth of an ise1 mutant of Saccharomyces cerevisiae. Genetic complementation and mapping studies demonstrated that ise1 was allelic to erg6, a gene required for the biosynthesis of the principal membrane sterol of yeast, ergosterol. Treatment of ise1 cells with BFA resulted in an immediate block in protein transport through the secretory pathway. Vacuolar...

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Identifiers

PMID: 8458343
DOI: 10.1002/j.1460-2075.1993.tb05727.x
PMCID: PMC413285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway.PMID 8458343Read ↗

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