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Article

GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7.

FEBS letters - 20 Dec 2014

Arst Herbert N, Hernandez-Gonzalez Miguel, Peñalva Miguel A, Pantazopoulou Areti

Abstract excerpt

Golgi Arf1-guanine nucleotide exchange factors (GEFs) belong to two subfamilies: GBF/Gea and BIG/Sec7. Both are conserved across eukaryotes, but the physiological role of each is not well understood. Aspergillus nidulans has a single member of the early Golgi GBF/Gea-subfamily, geaA, and the late Golgi BIG/Sec7-subfamily, hypB. Both geaA and hypB are essential. hypB5 conditionally blocks secretion. We sought...

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Identifiers

PMID: 25451223
DOI: 10.1016/j.febslet.2014.11.014
PMCID: PMC4266534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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