Article
BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae.
Genetics - 1 Jun 1994
Jackson C L, Képès F
Abstract excerpt
Brefeldin A (BFA) blocks protein transport out of the Golgi apparatus and causes disassembly of this organelle in mammalian cells. The primary effect of BFA is the release of the non-clathrin coat from Golgi membranes and vesicles. We sought to elucidate the mechanism of BFA action using a geneti...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brefeldin A
- Cell Nucleus
- Cloning, Molecular
- Cyclopentanes
- Endoplasmic Reticulum
- Fungal Proteins
- Gene Expression
- Genes, Fungal
- Genotype
- Golgi Apparatus
- Mammals
- Molecular Sequence Data
- Mutation
- Plasmids
- Repressor Proteins